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November 18, 1911

Quinin in the Preventive Treatment of Migraine and Anaphylaxis

JAMA. 1911;LVII(21):1712. doi:10.1001/jama.1911.04260110212026

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To the Editor:  —In a paper read before the German Medical Society of New York, Feb. 18, 1908 (Therapeutische Monatshefte, May, 1908), I tried to establish the fact that typical attacks of migraine had their origin in the gastrointestinal tract, and were due to auto-intoxication caused by the absorption of certain albuminoids. At the time the tendency was against my hypothesis, but subsequent developments in the causation of a varied series of vague diseased conditions are now being referred to as an outcome of the absorption of certain albuminoids giving rise to condition now known as anaphylaxis, to which class the syndrome known as migraine or hemicrania is now referred. I myself have been subject to such attacks; during an attack of gastro-intestinal disturbance, certain food products which I can at other times eat with impunity immediately cause an attack of migraine. This led me to attempt to find some

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