In 1889, Müller observed the increase of eosinophils in the sputum of bronchial asthma patients. Fink,1 in 1890, described the eosinophilia of the blood in this disease. Von Noorden,2 in 1892, in a study of the asthmatic's blood, observed that during paroxysms the eosinophils were much more numerous than in the intervals between attacks and that frequently repeated paroxysms gave the highest percentage of these cells. He reports a case in which, during freedom from symptoms, the eosinophils were 5 per cent., but after daily attacks for thirteen days, excepting a five days' interim, the percentage rose to 33 1/3.
Salecker,3 in 1907, in a study of seven cases, noted a slight lymphocytosis with a slight eosinophilia between attacks. During attacks with continuance of the spasm there was a leukocytosis, the increase being mostly of the eosinophils. As the paroxysm subsided the eosinophils decreased and in the course of
HERRICK WW. THE EOSINOPHILIA OF BRONCHIAL ASTHMA: WITH REPORT OF A CASE SHOWING EXTREME BLOOD CHANGES. JAMA. 1911;LVII(23):1836–1837. doi:10.1001/jama.1911.04260120026009
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