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Article
December 2, 1911

THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JAMA. 1911;LVII(23):1840-1843. doi:10.1001/jama.1911.04260120030013
Abstract

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SATURDAY, DECEMBER 2, 1911 

CARBOHYDRATE TOLERANCE AND THE HYPOPHYSIS CEREBRI  Noteworthy advances have been made in the last few years in elucidating the problems relating to the physiology and pathology of the hypophysis. Among these may be mentioned the favorable results of the partial removal of this gland in certain cases of acromegaly, and the demonstration by Paulesco and by Cushing1 and his co-workers that the total extirpation of this gland in animals is rapidly followed by death, whereas the partial extirpation is followed by very characteristic effects on growth and development. The latter results afford conclusive evidence that at least some cases of this disease are due to a hyperfunctioning of the hypophysis, something which has long been suspected, but not previously definitely proved.One of the most

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