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August 8, 1903

NEW INVESTIGATIONS CONCERNING THE FIXATION OF TETANUS TOXIN BY CEREBRAL TISSUE.

JAMA. 1903;XLI(6):376. doi:10.1001/jama.1903.04480030028012
Abstract

When cerebral tissue is mixed with tetanus toxin, there occurs some form of union between the two which has been spoken of as a neutralization of tetanotoxin, due to its combining with the lateral chains or receptors of the nerve cells. This phenomenon was studied especially by Wassermann and Takaki, and by them and others marshalled into line as one of the strongest supports of Ehrlich's side-chain theory of cytolysis and immunity. Some recent experiments by Besredka and others are of interest in connection with the study of toxins. Besredka1 finds that washed tetanized cerebral tissue (large quantity of tetanus toxin is added to the cerebral tissue of guinea-pigs, and after from six hours to three days the tissue is washed until the wash-water is wholly harmless when injected) produces fatal tetanus in mice in doses of one or two drops. This experiment certainly shows that more tetanotoxin is

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