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Article
December 30, 1911

GENERAL PARESIS, TABES AND SYPHILIS OF THE NERVOUS SYSTEM

Author Affiliations

Alienist and Neurologist to Bellevue Hospital; Consulting Neurologist to St. Vincent's and Manhattan State Hospitals; Neurologist to the University and Bellevue Dispensary; Professor of Mental and Nervous Diseases, University and Bellevue Hospital Medical College Dand DHospital DDollege NEW YORK

JAMA. 1911;LVII(27):2134-2137. doi:10.1001/jama.1911.04260120324014
Abstract

ETIOLOGY  In all three conditions mentioned in the title have as the primary cause syphilis. In general paresis and tabes there are no active elements of the primary infection present; that is, no spirochetes are found in the diseased tissues. We have rather the results which manifest themselves by inducing fibrosis of the nerve-tissues and blood-vessels. Probably 5 or 10 per cent. of those acquiring syphilis are affected with general paresis and tabes, and a like proportion with syphilis of the nervous system.We should divide these diseases into two classes, (a) general paresis and tabes being parasyphilitic, and (b) syphilis of the nervous system being directly due to infiltration of syphilitic material into the nerve-structures and vessels, with evidence of spirochetes. An important point is also the time between the infection of the primary disease and the appearance of the disease of the nervous system.

SYPHILIS AND PARASYPHILIS  In

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