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July 1, 1905


JAMA. 1905;XLV(1):40-42. doi:10.1001/jama.1905.52510010040002


PRINCIPLES OF SERUM THERAPY.  In the strict sense serum therapy means the injection of antitoxic or antibacterial serums for curative or prophylactic purposes; this is passive immunization or direct serum therapy. Active immunization, in which the tissues of the individual are induced to form antitoxins or antibacterial substances as a result of vaccination or protective inoculations, may be considered as indirect serum therapy. We may, therefore, include the latter as one of the serotherapeutic measures.Bearing in mind the significance of the terms active and passive immunization, and the fact that they may be used for curative and prophylactic purposes, the various procedures may be classified as follows:

I. PROPHYLACTIC INJECTIONS.  A. Active immunization, in which vaccination and protective inoculations are included, as with the organisms of typhoid, cholera and plague. Depending on the material injected, the result is the formation of antitoxins or antimicrobic substances (amboceptors); agglutinins