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The prevalent use of chloroform as the anesthetic of choice in many districts of the United States and its use throughout this country almost to the exclusion of ether, and this in spite of the increasing evidence and more or less general knowledge of its grave dangers, induces me to report the following cases.
I hesitate to report them only because I am unable to give pathologic data concerning them. The clinical courses, however, of Cases 1, 2 and 3 are so typically those recently attributed to chloroform as the causative agent in producing acute degenerative changes in the liver and an acid intoxication, that I think little doubt can be entertained of the diagnosis. The fact that such changes have been induced experimentally in animals by chloroform, and that clinically nothing else seems to explain the condition so aptly, has led, I think, to the general acceptance of the
MONROE PW. CHLOROFORM FATALITIES: A REPORT OF CASES. JAMA. 1912;LVIII(2):89–90. doi:10.1001/jama.1912.04260010091005
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