As the result of an immense amount of investigation on the part of physiologists, both in America and in Europe, it has been shown that carbon dioxid is not merely a waste product of the body. On the contrary it is one of the most important of the body's hormones, exercising a regulative influence on the action of the heart, on the tonus of blood-vessels, and especially on the respiration. In fact, breathing in ordinary life is practically dependent on the stimulation afforded to the respiratory centerby the carbon dioxid brought to it in the blood. In the demonstration of this exceedingly important fact the Italian school of physiologists has played an important rôle. In particular, the late Professor Mosso of Turin, in his important studies on mountain sickness, was led to conclude that this condition was essentially due to a decrease in the carbon dioxid of the body, a
LEVI E. THE CLINICAL USE OF CARBON DIOXID WITH OXYGEN. JAMA. 1912;LVIII(11):773–774. doi:10.1001/jama.1912.04260030171013
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