At present I am compiling my records of about 200 cases of meningitis in which, in all, about 600 lumbar punctures were done. Most of the cases were studied in the present epidemic at Dallas, Tex. I thought it would be desirable, before waiting for the compilation of the complete records, to write a preliminary note on an improvement in the method of administering intraspinally the antimeningitis serum which I have been using for the past seven months and which I believe has now definitely proved its efficiency and superiority over the old method of administration.
The present method of standardizing the antimeningitis serum, as generally accepted, is by determining the opsonic index and by similar immune-serum tests. There is, however, no measure of efficiency placed on the serum such as we have in the case of diphtheria or tetanus antitoxin; the dose is therefore measured entirely by volume. Since
SOPHIAN A. A NEW METHOD FOR CONTROLLING THE ADMINISTRATION OF SERUM IN EPIDEMIC MENINGITIS: PRELIMINARY NOTE. JAMA. 1912;LVIII(12):843–845. doi:10.1001/jama.1912.04260030241005
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