[Skip to Content]
[Skip to Content Landing]
March 30, 1912


Author Affiliations

Assistant Surgeon, Manhattan Eye and Ear Hospital; Assistant Ophthalmic Surgeon, Presbyterian Hospital, Out Patient Department NEW YORK

JAMA. 1912;LVIII(13):925-929. doi:10.1001/jama.1912.04260030323008

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Trachoma is a disease of the conjunctiva, in which there is a characteristic connective-tissue hyperplasia. It is marked by a proliferation of lymphoid cells. The follicles formed by this proliferation tend to degenerate and to become encapsulated by the newly formed connective tissue. As a result of this inflammatory process, newly formed blood-vessels penetrate these follicles. They become distended with fluid, push their way above the surface of the conjunctiva, finally becoming degenerate, break down, and the overlying conjunctiva is replaced by scar tissue, and thus, step by step, the entire conjunctiva becomes destroyed. As a result of this chronic inflammatory process, connective-tissue changes take place in the deeper structures of the lid, normal blood-vessels become obliterated, all glandular secretion is checked and there is produced a general atrophy of the lid.

It was a little more than a hundred years ago that the significance of this disease began to

First Page Preview View Large
First page PDF preview
First page PDF preview