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A complex but interesting series of phenomena are known to take place when certain living vegetable cells invade an animal tissue and compete with its living units for nutrition. The life and well being of invading bacteria usually means death to the neighboring tissue cells. This issue is resisted most vigorously by those cell elements immediately concerned in protecting the organism. In the more simple forms of life these influences are less complex and are confined to so-called immediate effects, while in the human organism we have not only the immediate but also the remote influences of active efforts at resistance. It is evident that the more complex the organism the more multiple and intricate will be these manifestations. A complex and highly differentiated organism has a temperature regulating mechanism which is easily deranged. It has numerous organs whose secretions and functions may be altered, a highly developed nervous system
KALES JD. INFLAMMATION AND MICROBES. A LECTURE. JAMA. 1895;XXIV(6):194–196. doi:10.1001/jama.1895.02430060012001c
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