Some five or six years ago, in a paper on the opsonins, Professor, now Sir Alfred Wright incidentally mentioned that in a case of "brawny swelling" he had used successfully 60 gr. of citric acid administered every two or three hours. Under the old conditions as to therapeutic knowledge such a case gave one a feeling of helplessness and a loss of confidence in the science of medicine. I had previously lost a patient whose case was typical. Beginning as a mild infection in the mouth, showing practically no objective symptoms, it rapidly intensified. No antiseptics, no constitutional remedy which was suggested seemed to have the slightest beneficial effect. The swelling increased in geometrical ratio. The lip, cheek and then the neck were involved. To relieve the tension, before the neck was specially involved, deep incisions were made externally and internally into the cheek and lip. The only result was
HEMENWAY HB. THE THERAPEUTIC USE OF CITRIC ACID AND THE CITRATES. JAMA. 1912;LVIII(14):992–995. doi:10.1001/jama.1912.04260040008003
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