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Urea being the final product of tissue metamorphosis and apparently playing no rôle whatever in our economy, it was natural to consider it a waste material, of which our system should rid itself. Finding this material diminished in various affections it was a priori considered that the system must be overloaded with this effete material, urea.
That urea is even yet considered a toxic body by many, is apparent from the numerous articles attributing toxic effects to this substance. The recent article by Dr. J. Nelson Teeter, on "The Relation of Urea to Epilepsy," which appeared in the January number of the American Journal of Insanity, has caused me to write my observations and experiments in regard to the toxicity of urea.
Perhaps no one has done more toward fathoming the mysterious depths of auto-intoxication than has Bouchard; to him my experiments are due, nor do my experiments differ from
COOK RH. THE NON-TOXICITY OF UREA. JAMA. 1895;XXIV(8):266. doi:10.1001/jama.1895.02430080008001c
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