This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
—John M., carriage-builder, aged 32, previously healthy, had a typical attack of typhoid six years ago, in the Bryn Mawr Hospital. One month after recovery he noticed, in the middle of the right tibia, an area of tenderness and edema measuring about 3 inches in length. The condition was only slightly painful and did not interfere with his work. It inconvenienced him greatly, however, because any accidental abrasion in the affected region was very slow in healing; behaving, in fact, like an ordinary varicose ulcer and yielding only to firm strapping and bandaging. The condition continued without intermission, and the area involved increased in extent upward, until within 1 inch of the tubercle of the tibia.
—Nov. 20, 1911, a dose of 90 million dead typhoid bacilli was injected in the right ankle and ten days later, 180 million. Following the second injection there was an intense local
Sharpless FC. NOTE ON TREATMENT OF TYPHOID PERIOSTITIS BY VACCINES. JAMA. 1912;LVIII(15):1114. doi:10.1001/jama.1912.04260040130011
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: