In addition to the various chemical ingredients constantly found in all animal cells, and sometimes referred to as the primary constituents, there are also secondary constituents which are not found in all cells, at least in recognizable quantities, of which perhaps the most important are fat and glycogen. Glycogen has until recently evaded successful study because it is very soluble in water, and also rapidly disappears from the cell after its death, both of which facts make it difficult to secure material in condition for examination. Methods have been devised, however, which permit of securing well-stained microscopic preparations from fresh material, and control by chemical means shows that the microscopic appearances are a reliable indication of the quantity of glycogen actually present in the tissues. During the process of evolution of these methods many and often erroneous observations and deductions have been made, which have recently undergone a clearing up
GLYCOGEN IN PATHOLOGIC CONDITIONS.. JAMA. 1905;XLV(9):633–634. doi:10.1001/jama.1905.02510090055006
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