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Wille, several years ago, made an exceedingly valuable analysis of the psychoses due to syphilis, which he found were divisible into the following classes: 1, irritative psychoses based on cerebral anemia following syphilitic infection even from its very beginning; 2, simple inflammatory psychoses due to meningitis and cerebral softening; 3, neoplastic psychoses proceeding from cerebral meningeal gummata. Griesinger states that when acute mental disease affects patients during the secondary stage of syphilis, it will be chiefly those whose brain is organically affected, who have previously presented symptoms of abnormal cerebral activity or who come from neurotic families.
Wille says that mental symptoms may appear two months, or even two weeks after infection, certainly with the onset of the secondary symptoms. Hildebrand has had very similar experience.
Leubuscher was the first to establish the existence of mental symptoms during the secondary period. Prior to his article these had been regarded as
LYDSTON GF. NERVOUS DISEASE IN EARLY SYPHILIS. JAMA. 1895;XXIV(9):321–325. doi:10.1001/jama.1895.02430090023001h
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