—It would seem superfluous to say a word here on the pathology of this affection. But the nature of the new treatment demands that we refresh our memory on some points of it before certain therapeutic questions to be dealt with presently may appear clear. The result of my observations and researches have convinced me beyond a doubt that tuberculosis, in the stage of lesions, particularly when pulmonary cavities, intestinal ulcers, etc., exist becomes a mixed infection, due to the introduction of various other pathogenic microbes besides the bacillus of tuberculosis in the specific wound. Myriads of germs of the air, water and food gain access to tuberculous lesions and complicate the primary disease to a very grave degree. The destruction of tissue by these germs, the production of new mixed poisons, perhaps more dangerous sometimes because of chemic combinations, are largely responsible for the irregular chills, fevers
PAQUIN P. ANTI-TUBERCLE SERUM.THE TREATMENT OF CONSUMPTION BY SEROTHERAPY— REPORT AND PRESENTATION OF CASES TREATED— EXHIBITION OF SERUM, ETC. JAMA. 1895;XXIV(10):341–346. doi:10.1001/jama.1895.02430100001001
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