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Every organic stricture of the urethra, with the possible occasional exception of the traumatic variety, is associated with some form of chronic inflammation due to a persistent cryptic state of infection. Indeed, it may be confidently asserted that the ordinary type of stricture, the so-called inflammatory type, is primarily merely a phase of chronic urethritis. Owing to the overshadowing significance of its mechanical effect on the upper urinary tract, stricture is too frequently regarded as a complete morbid entity. The rôle of local infection is by no means a minor one, however, when the possible results are considered. The danger lies not in the urethra itself, but in the propagation of the infection into the surrounding tissues. Depending on conditions, there may occur here a variety of states of inflammation, from a pea-sized sclerotic nodule, discovered only by palpation on a sound, to the most acute, rapidly spreading, gangrenous phlegmon.
SILVERBERG M. THE PERIURETHRAL COMPLICATIONS OF STRICTURE. JAMA. 1912;LVIII(17):1275–1276. doi:10.1001/jama.1912.04260040291009
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