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Article
September 2, 1905

ACID INTOXICATION, AND LATE POISONOUS EFFECTS OF ANESTHETICS.HEPATIC TOXEMIA. ACUTE FATTY DEGENERATION OF THE LIVER FOLLOWING CHLOROFORM AND ETHER ANESTHESIA.

JAMA. 1905;XLV(10):691-696. doi:10.1001/jama.1905.52510100025002c
Abstract

In January, 1905, there occurred in our practice a case of gangrenous ovarian cyst with twisted pedicle. The patient was operated on and the case terminated fatally four days and a half later. The clinical picture was a very unusual one. Although we were aided in the conduct of the case by four consultants, a gynecologist, an internist, a neurologist, and a pathologist of more than ordinary ability, no definite diagnosis of the cause of the singular symptoms could be made. The parents of the child, fortunately, were intelligent and considerate and, realizing the importance to humanity and to science of ascertaining the exact cause of death, as the first step to the prevention of a similar result in other cases, permitted a postmortem examination. This was made with the greatest thoroughness, gross, microscopic and bacteriologic, and yet even then the cause of death was obscure and remained so until

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