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Article
April 27, 1912

RELATION OF VARIETIES OF STREPTOCOCCI: WITH ESPECIAL REFERENCE TO EXPERIMENTAL ARTHRITIS

Author Affiliations

CHICAGO

From the Laboratory of St. Luke's Hospital.

JAMA. 1912;LVIII(17):1283. doi:10.1001/jama.1912.04260040299021
Abstract

It is the purpose of this statement to call attention to certain facts observed in connection with a series of animal experiments on the relation of various kinds of streptococci to experimental arthritis. Injection of Streptococcus hœmolyticus intravenously into rabbits practically always gives rise to arthritis and tenosynovitis which may be monoarticular or polyarticular. This is true regardless of the source of the organism as I have shown in a previous paper.1 When given in moderate doses rarely do the streptococci localize elsewhere. In large doses they are prone to produce myocardial abscesses and hemorrhages and occasionally also typical vegetative endocarditis. The latter lesion, however, is not common, probably because sufficiently large doses cannot be given without quickly killing the animal by general septicemia.

A streptococcus recently isolated from cases during an epidemic of sore throat in Chicago,2 has been tested on animals and in every instance (four

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