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SATURDAY, MAY 4, 1912
In 1904 Aschoff described certain peculiar, microscopic nodules in the myocardium, which he regarded as specifically characteristic of acute articular rheumatism. These nodules are made up of large cells with one or more large, irregular or polymorphous nuclei, and often but not always of small and large lymphocytes as well as ordinary polymorphonuclear leukocytes, especially at the margins. Aschoff named the process "myocarditis rheumatica."Since then these peculiar formations have been made the subject of three or four communications in German periodicals, most recently by Fraenkel,1 who discusses their nature and significance on the basis of a careful investigation of twenty cases, in eight of which there was a definite history of rheumatism, while in most of the
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. JAMA. 1912;LVIII(18):1376–1378. doi:10.1001/jama.1912.04260050052018
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