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Article
September 9, 1905

ACID INTOXICATION, AND LATE POISONOUS EFFECTS OF ANESTHETICS.HEPATIC TOXEMIA. ACUTE FATTY DEGENERATION OF THE LIVER FOLLOWING CHLOROFORM AND ETHER ANESTHESIA.

JAMA. 1905;XLV(11):754-759. doi:10.1001/jama.1905.52510110008001a
Abstract

Stocker,5 in 1895, reports an operation for strangulation of pedicle of ovarian cyst. A gangrenous pedicle was found and cyst and pedicle were removed. Stocker makes no mention of the anesthetic, but in Cohn's article referred to later he mentions chloroform as the anesthetic used. Probably this statement was made to Cohn personally. Shortly after the operation icterus was noted, the patient became restless, finally became comatose and died. An acute yellow atrophy of the liver was found at autopsy. Stocker believes that the atrophy resulted from the absorption of toxins from the strangulated and gangrenous pedicle. He does not lay much stress on the anesthetic used.

Victor Bandler,14 in 1896, reports a case of late chloroform poisoning from Wölfer's clinic.

Patient.  —Male, 42 years old; glass blower by occupation; apparently in good health, but a heavy beer drinker, often taking as many as 101 daily, was operated

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