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In 1883 Koch recognized microscopically in the stools of cholera patients, and by proper technic obtained in pure culture, the Vibrio cholerœ, which stands to-day as the unquestioned cause of Asiatic cholera. The organism may be cultivated from the stools in every case of cholera, and is never found in the stools of normal individuals, except in the case of non-susceptible persons who are often encountered in the presence of an epidemic. Such persons are often a source of danger as unsuspected "cholera carriers." No other intestinal disease is accompanied by the presence of the vibrio of cholera.Typically the cholera vibrio is about 1.5 microns long and one-fourth as broad. When freshly cultivated from the stools the cells of young cultures have the so-called comma shape which has given the organism the name of the comma bacillus. The form in reality is that of a segment
IMMUNITY. JAMA. 1905;XLV(11):788–789. doi:10.1001/jama.1905.52510110044002
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