Through the researches of embryologists it has been learned that, during the development of the more highly differentiated multicellular organisms, the cell divisions by karyokinesis, which are at first diffusely and more or less evenly distributed over the whole "cell state," gradually come to be definitely localized and regularly grouped. This localization and grouping of the karyokineses is a process which stands in intimate causal relation to the shaping of the form of the embryo, inside and out, as well as to the differentiation of the individual organs. In the places, then, where karyokinetic figures are met with in numbers, we have to deal with "construction centers" of the living substance, with areas of most intense growth; a study of the disposition of areas rich in karyokineses is, therefore, of the greatest importance for the localization of growth processes in a developing organism.
In the earliest embryonic period of higher
CELL PROLIFERATIONS IN GROWTH CENTERS AND THEIR RELATIONS TO REGENERATION AND TO TUMOR FORMATION.. JAMA. 1905;XLV(11):791–792. doi:10.1001/jama.1905.02510110047005
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