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Article
September 16, 1905

METHEMOGLOBIN AS A FACTOR OF CONSERVATIVE METABOLISM.

Author Affiliations

Neurologist to the Hospital for the City and County of Denver. DENVER, COLO.

JAMA. 1905;XLV(12):826-830. doi:10.1001/jama.1905.52510120010001b
Abstract

DEFINITIONS.  Hemoglobin (Hb) is a crystallizable body which constitutes the largest portion of the colored corpuscle. It is a respiratory pigment, has the power to attract oxygen and also other gases. (Kirk.)Hemoglobinemia is a condition in which the hemoglobin is dissolved out of the red corpuscle and is held in solution in the serum. (Gould.)Oxyhemoglobin (O2Hb) results when hemoglobin is united molecule for molecule with oxygen. It is the characteristic constituent of the red corpuscle to which the scarlet color of arterial blood is due. (Gould.)Reduced hemoglobin is the result of deoxidation of oxyhemoglobin. (Gould.)Methemoglobin (Met Hb) is a modified form of hemoglobin. It is the product either of incomplete decomposition of hemoglobin or of its excessive oxidation. The oxygen is more firmly combined in it than in oxyhemoglobin. (Gould.)Methemoglobinemia is the presence of free methemoglobin in the blood. (Gould.)1To the

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