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May 25, 1912

Nephritis: An Experimental and Critical Study of Its Nature, Cause and the Principles of Its Relief.

JAMA. 1912;LVIII(21):1635-1636. doi:10.1001/jama.1912.04260050309038

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This is a book full of fresh, original thought. It is a special plea for the author's theory of nephritis, being an extension of his theory of edema, which has been favorably received by pathologists, though still under judgment.

The author does not consider in detail the histology of the kidneys, hut rather their physiochemical structure. He believes that "all the changes that characterize nephritis are due to a common cause—the abnormal production or accumulation of acids in the cells of the kidney"s and gives the details of numerous experiments to prove this. The albumin of albuminuria, he believes, comes from the urinary membranes, not from the blood, that is, it is due to a solution of the solid colloid which makes the membranes. He shows what is the effect of acids and alkalies on solid colloids, such as fibrin and gelatin and later on the tissues.

From his experiments

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