The object of this study1 was to ascertain the freezing points of the blood and of the urine in pneumonia; to determine the relation of such findings to the course of the disease; and to note any possible bearing the same may give with regard to the prognosis of this disease. Before discussing the methods employed and the observations made in the cases studied, it will be well to mention briefly the work of other investigators who have used cryoscopy in their researches.
A BRIEF REVIEW OF CRYOSCOPY AS USED IN MEDICINE.
As early as 1871, De Coppet2 showed that the freezing point of water is lowered a definite amount by the addition of a molecule or proportionate quantity by weight of any soluble substance. Little was done, however, following this finding until Raoult3 studied the freezing points of various solutions and derived his important laws. Van
SCHMIDT FE. THE FREEZING POINTS OF BLOOD AND OF URINE IN PNEUMONIA. WITH DESCRIPTION OF A NEW METHOD. JAMA. 1905;XLV(13):894–900. doi:10.1001/jama.1905.52510130014001d
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