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Tuberculosis is as old as the history of medicine, and its contagiousness was assumed but not demonstrated at a very early period. Klemke in 1843, but more particularly Villemin in 1865, demonstrated the infectiousness of tuberculosis by animal experiments, and these results were substantiated later by such investigators as Klebs, Chauveau, Baumgarten and Conheim. As the era of specific microbic etiology developed search for the germ of tuberculosis began and for a period a number of organisms were erroneously considered as the cause. Of these the Monas tuberculosum of Klebs obtained considerable prominence. Baumgarten first saw the tubercle bacillus in sections of tubercular material from which the tissue cells had been dissolved by potassium hydroxid, and at almost the same time Koch succeeded in demonstrating its presence in all tubercular lesions by a special staining method. He eventually obtained the organism in pure cultures with which he
IMMUNITY. JAMA. 1905;XLV(14):999–1000. doi:10.1001/jama.1905.52510140045002
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