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October 7, 1905

UNTOWARD EFFECT OF ADRENALIN IN THE URETHRA.

JAMA. 1905;XLV(15):1086. doi:10.1001/jama.1905.52510150050004a

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Abstract

A patient whom I have been treating for stricture of the urethra, and in whom I have passed sounds for several months, came to my office in his usual good spirits, and in perfect health. After passing a No. 27 French sound, there was some little bleeding from the urethra, which I attempted to check with a solution of adrenalin chlorid, 1-4000, injected in the urethra with an ordinary glass syringe, filling the entire anterior urethra. The following symptoms occurred instantaneously: Lividity or pale lead color of the skin; the eyes set and glassy, the patient crying out, complaining of a bursting sensation in his abdomen, chest, neck and head, saying the top of his head would burst open; a tingling and pressure in hands, arms, legs and feet; vomiting of a projectile character, followed by complete collapse, without loss of consciousness, lasting for a period of ten minutes; respiration

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