The observation that the leucocytes in the circulating blood are increased after eating is an old one. First noted by Nasse in the middle of last century, the observation was then incapable of rigorous scientific proof, but was finally subjected to accurate tests by Limbeck in 1890. Since then numerous hematologists have convinced themselves that a digestion leucocytosis occurs, though there have been doubters who claimed that the varying counts at different times of the day are due to a normal fluctuation independent of the consumption of food. It was natural that some attempt should be made to apply this observation in the physiology of the blood to the study of the pathology of digestion. It was fair to assume that lesions of the stomach might be followed by changes in this digestive leucocytosis, and Muller, in 1890, was the first to announce that this was the case. His
DIGESTION LEUCOCYTOSIS AND CANCER OF THE STOMACH.. JAMA. 1905;XLV(15):1088–1089. doi:10.1001/jama.1905.02510150052006
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