The so-called hypernephroma is undoubtedly the most frequent malignant tumor in the kidneys. Until quite recently these tumors were regarded as originating in aberrant remnants of adrenal tissue most commonly believed to occur immediately under the capsule of the kidney. This view was advanced by Grawitz in 1883, and the tumors in question are frequently referred to as "Grawitz tumors." This conception of the origin of these tumors was based largely on the similarity between the tumor cells and the cells in the adrenal cortex. Specks and patches of a yellowish or grayishyellow paler than the renal cortex are frequently found in the surface of the kidney, and these structures are held, usually, to be bits of misplaced adrenal tissue. Renal hypernephromas consequently have been regarded as a good illustration of Cohnheim's supposition that malignant tumors develop from misplaced embryonal matrix, a conception of which we hear much less now
ABERRANT EPITHELIAL STRUCTURES IN THE CORTEX OF THE KIDNEY AND THEIR RELATION TO THE SO-CALLED HYPERNEPHROMA. JAMA. 1914;LXII(1):44–45. doi:10.1001/jama.1914.02560260052025
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