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October 14, 1905


JAMA. 1905;XLV(16):1171. doi:10.1001/jama.1905.02510160045008

According to Woodyatt, who describes a remarkable case of diffuse carcinomatous infiltration of the bones, with softening, in a woman of 40, the primary tumor being situated in the breast, carcinomatous bone metastases, which are of rather frequent occurrence, may develop as multiple, circumscribed nodules, in which osteoplastic processes have the upper hand, and more rarely as diffuse, soft infiltrations in which bone resorption occurs.1 When fairly widespread, this latter form has been called carcinomatous osteomalacia (first described by Hawkins in 1841). Because carcinomatous osteomalacia, though a very rare condition, may be confounded with true osteomalacia and with ostitis deformans, it merits special notice. In six of the seven generalized cases unearthed by Woodyatt, the primary carcinoma was situated in the breast; in the seventh its seat appears to have been unknown. Whether the malacic changes in the bones in any way are due to substances elaborated by the

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