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November 21, 1903

THE PROTOPLASMIC ACTIVITY OF THE RENAL EPITHELIUMAS DETERMINED BY THE ELIMINATION OF PIGMENTS INJECTED INTO THE CIRCULATION.

JAMA. 1903;XLI(21):1248-1252. doi:10.1001/jama.1903.92490400008001b
Abstract

INTRODUCTION.  The question of the functional activity of the renal epithelium is ever one of deep interest, both to the physiologist and to the pathologist.It will be remembered that Bowman's theory concerning the separation of the urine by the kidney was originally founded on anatomic findings entirely and not on experimental evidence. According to this view, the glomeruli separate the watery portion of the urine and the freely diffusible substances, while the specific ingredients of the urine, viz., the urea, uric acid, etc., are secreted by the cells of the uriniferous tubules.Bowman's theory was replaced for a time by that of Ludwig when the latter investigator and his school showed the close relationship which exists between the circulation of blood in the kidney and the amount of urine separated. This theory held that the separation of urine by the kidney is purely a physical process, the blood-pressure

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