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October 28, 1905


JAMA. 1905;XLV(18):1328. doi:10.1001/jama.1905.02510180044005

There are many points of extreme interest in connection with hydrophobia. Thus, the affinity of the as yet unknown virus for the nervous tissue can not but excite our curiosity, but not to any higher degree than does the very highly specialized mode of elimination selected by this virus, namely, by way of the saliva. There has been some doubt expressed as to whether or not the saliva of human beings suffering from hydrophobia contains the virus. There seems to be no question, however, but that in many cases the saliva of hydrophobic patients is virulent. Recently Bertarelli1 demonstrated such to be the case in an instance of hydrophobia in a boy. It is interesting to note that Bertarelli found the saliva in this case to be virulent after being filtered through a Berkefeld filter No. 5, thus confirming the observations by Remlinger and others that the virus of