The formations designated by Seigert as corpora colloidea, and commonly known as corpora amylacea, have been observed in various organs. Morgagni saw them first in the prostate gland in 1723. Virchow found them later in the brain, spinal cord, at the neck of the bladder, and in the so-called female prostate (delicate tubular glands surrounding the female urethra). Friedrich found them in the lung; Lubarsch in a tumor of the supra-renal capsule, and Hildebrand in a malignant growth from the sternum.
Widely varying hypotheses concerning the histogenesis of these bodies have been proposed by those whose attention they have attracted, the same after painstaking investigations, but none has led to an agreement as to the meaning of the observations made.
Morgagni compared the concretions macroscopically with snuff particles, and regarded them as a pathologic product of precipitation in prostate secretion. Virchow remarked the gray-blue nuance of color upon application of
EASTMAN JR. THE ORIGIN OF CORPORA AMYLACEA IN THE PROSTATE GLAND. JAMA. 1897;XXIX(4):158–162. doi:10.1001/jama.1897.02440300010001b
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