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Article
November 11, 1905

PSEUDO-SCLEROSIS (DIFFUSE SCLEROSIS), WITH THE REPORT OF A CASE WITH NECROPSY.

JAMA. 1905;XLV(20):1455-1459. doi:10.1001/jama.1905.52510200001001
Abstract

In 1883 Westphal1 reported two cases presenting a symptom-complex resembling that of multiple sclerosis, but in which microscopic examination of the brain and cord gave negative results. To this condition was given the name pseudo-sclerosis. Since this time a number of cases (14) presenting this condition have been reported, mostly by German observers. It will be noted in reading the abstracts of these cases, which are given below, that the brain and cord in a number of them were unusually firm. A similar condition of hardness, although possibly more marked, is observed in another group of cases also presenting a symptom-complex resembling that of multiple sclerosis, in which microscopic examination of the brain and cord shows a proliferation of neuroglia and vascular disease. To this condition the term diffuse sclerosis has been applied, and a number of cases have been reported, mostly by German authors.

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