[Skip to Navigation]
Sign In
Article
July 31, 1897

RELATION OF THE ALLOXURIC BODIES TO GOUT OR A URIC ACID DIATHESIS.

Author Affiliations

ASSOCIATE IN MEDICINE, JOHNS HOPKINS UNIVERSITY, AND ASSISTANT RESIDENT PHYSICIAN, JOHNS HOPKINS HOSPITAL. BALTIMORE, MD.

JAMA. 1897;XXIX(5):216-221. doi:10.1001/jama.1897.02440310014001c
Abstract

In the German contributions on the studies of metabolism in various diseases which have appeared since 1895, one meets very frequently with the terms "alloxurkörper" or alloxuric bodies, and "alloxurbasen" or alloxuric bases. Especially is this the case in the study of the metabolism of gout. A brief explanation of the circumstances leading to the adoption of these terms may be of interest.

In 1869 Miescher isolated a phosphorus-containing substance from the nuclei of pus cells to which Hoppe-Seyler gave the name nuclein. Previous to this date, xanthin and hypoxanthin had been known to chemists, but it was not until some time later that Kossel demonstrated that yeast nuclein could be made to yield phosphoric acid, hypoxanthin and an albuminous body, by the action of boiling water. Since then, hypoxanthin has been definitely proven to be derived from the nuclein of animal cells as well. In addition to hypoxanthin, four

Add or change institution
×