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November 11, 1905


JAMA. 1905;XLV(20):1496-1497. doi:10.1001/jama.1905.52510200042002

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ACTINOMYCOSIS.  Actinomycosis is a chronic infectious disease of man and animals, the lesions of which present, characteristically, a central mass of purulent and necrotic material containing colonies of "ray fungi," about or through which is disposed an abundant growth of granulation or fibrous tissue. In young or rapidly progressing lesions the amount of purulent material is large, while in older lesions well formed connective tissue is more conspicuous. The disease prevails especially among cattle, although it is met occasionally in the horse, hog, sheep, dog, cat and other animals; man is infected not infrequently.Although the threads of fungi had been found in diseases resembling actinomycosis in 1845 and later, Bollinger, in 1877, gave the first accurate description of the disease in cattle, and in 1878 J. Israel described it as a new disease in man. A short time later Ponfick demonstrated the identity of bovine and human actinomycosis.The

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