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March 21, 1914

THE INTRASPINAL INJECTION OF SALVARSANIZED SERUM IN PARESIS

JAMA. 1914;LXII(12):903-907. doi:10.1001/jama.1914.02560370011005
Abstract

This is a preliminary report of the treatment of general paralysis of the insane with salvarsanized serum.

The method used is that described by Swift and Ellis1 and first used by them in cases of tabes. It is an attempt to influence the disease by introducing serum from a salvarsanized patient into the cerebrospinal fluid. The ordinary dose of salvarsan is injected intravenously, and one hour later a quantity of blood withdrawn (about 40 c.c.) sufficient to produce 12 c.c. of serum. The serum is heated for half an hour at 56 C. (132.8 F.) and diluted to 30 c.c. with normal salt solution. This mixture is then injected by gravity into the spinal canal after the withdrawal of an equal amount of fluid. The patients are then kept in bed for at least twenty-four hours.

It is not proposed to discuss the rationale of the method, but only

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