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March 21, 1914


JAMA. 1914;LXII(12):914-915. doi:10.1001/jama.1914.02560370022011

The spinal administration of salvarsanized serum in the treatment of syphilis of the nervous system marks an important epoch in serotherapy. This mode of treatment, devised by Swift and Ellis, offers great promise for the future. The literature now contains records of experiences which indicate its efficiency in paresis and tabes. The originators of the method have controlled the intraspinal injections by repeated examinations of the spinal fluid and by a study of the subsequent clinical features of their cases. They feel that "there is definite evidence that this form of treatment has a curative action on the syphilitic process."1 The return of an abnormal spinal fluid to normal, as the result of treatment, has been marked; and in many cases there has been an improvement in symptoms. Hough,2 in his report of four cases, states that "we see pronounced improvement in the four reactions in all, and symptomatic in

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