While scattered reports of the occurrence of typhoid bacilli in the blood of typhoid patients extend over a period of twenty years, it is only within the last five or six years that published accounts of larger series of cases occur, and it remains for the present workers to demonstrate to the practitioner what I believe to be the case, that blood cultures in typhoid fever afford a surer and earlier means of diagnosis than the Widal reaction and are perfectly feasible in family practice.
The earliest publication on blood cultures in typhoid I have been able to find is that of Fraenkel1 in 1885. This observer in seven cases demonstrated the bacilli in the blood in one case. Twelve years later Künau2 reported that he had demonstrated the bacilli in eleven out of forty-one cases. In this country Cole,3 of Johns Hopkins, in 1901, in fifteen
DUFFY R. CULTURES FROM THE BLOOD IN TYPHOID.REPORT ON EXAMINATION OF EIGHTY-EIGHT CASES. JAMA. 1905;XLV(21):1558–1560. doi:10.1001/jama.1905.52510210028002d
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