Within the past eighteen months a new hope has dawned in the treatment of a disease heretofore regarded as hopeless: I refer to the use of benzol (benzene, C6H6) in the leukemias, the history of which dates from the publication of Koranyi's article in July, 1912. Koranyi's clinical use of this chemical was prompted, it should be said, by an almost accidental run of cases in Dr. Barker's clinic at the Johns Hopkins Hospital in 1909. These cases, briefly, were of three young girls whose occupation brought them into contact with crude benzol in the manufacturing trade; each presented evidences of a grave aplastic anemia and a striking leukopenia, and two of the three died. Prompted by this series of cases, Dr. Selling,1 of the same institution, undertook certain experimental work, by which he demonstrated a powerful leukotoxic action of the drug.
On this ground Koranyi
SMITH FH. BENZOL TREATMENT IN TWO CASES OF LEUKEMIA. JAMA. 1914;LXII(12):921–925. doi:10.1001/jama.1914.02560370029015
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