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November 21, 1896


JAMA. 1896;XXVII(21):1109-1110. doi:10.1001/jama.1896.02430990033005

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We have a good deal yet to learn concerning the action of various poisons upon the nervous system and particularly as to the effects induced by the group of infectious diseases. A growing experience has taught that nerve-fibers and nerve-cells may suffer in numerous ways through the deleterious influence of the agencies just named. We may thus have inflammation, hyperplasia, degeneration and sclerosis in white or gray matter in varying distribution, with corresponding diversity of symptoms. There are, however, many conditions in which, despite the presence of the most profound and pronounced symptoms, no lesion is demonstrable. The alterations that exist under these circumstances must therefore be looked upon as of the intangible nature which for the present we must be satisfied to designate nutritional, chemic or toxic. When recovery takes place these changes may disappear and leave no trace of their previous existence. On the other hand they may

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