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March 28, 1914


JAMA. 1914;LXII(13):977-980. doi:10.1001/jama.1914.02560380001001

A discussion of the autogenetic theories of the etiology of cancer invariably leads one ultimately to the hypotheses originally formulated by Thiersch1 and by Cohnheim.2 Hansemann,3 Imbarsch,4 Krompecher,5 Jbiorrmann6 and a number of others follow Thiersch's lead, and believe that a disturbance of the normal restraining influence of one tissue on another is in a large measure responsible for the lawless proliferation of the cancer cell, while Ribbert7 is probably the foremost present advocate of the embryonal inclusion theory.

Janeway8 has recently made an interesting contribution to the subject. His conclusions may be briefly summarized as follows: The essential change applicable to all cases in the transition of somatic cells into cancer cells is primarily of the nature of a degeneration, which, in one class of cases, is dependent on the existence of a previously isolated group of cells, in another class on

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