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March 28, 1914


JAMA. 1914;LXII(13):996-999. doi:10.1001/jama.1914.02560380020007

INTRODUCTION  If about one-fifth of the pancreas of a dog with its artery and vein be properly implanted under the skin of the abdomen, the graft will live. Later, the remaining four-fifths of the gland may be extirpated in toto without causing more than a transient glycosuria, the graft serving to prevent an outspoken diabetes. If after the animal has recovered from the second operation the encapsulated rest be enucleated, severe diabetes supervenes. On the other hand, the blood of depancreatized animals has not been found to possess positive diabetogenous powers. This experiment embodies the chief supports for the conception that the pancreas elaborates a "something" whose presence in the body is in some way necessary for the normal utilization of sugar. It is generally assumed that this "something" (internal secretion) leaves the pancreas by way of the blood-stream, that is, through the pancreaticoduodenal and pancreatic veins.Numerous attempts have

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