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March 28, 1914


JAMA. 1914;LXII(13):1002-1004. doi:10.1001/jama.1914.02560380026010

The fact that the formation of proteolytic enzymes in the blood may be stimulated through the parenteral introduction of proteins into the organism led to the discovery of such enzymes in certain normal and pathologic conditions in which complex proteins are swept into the circulation. The process of cleavage through these enzymes takes place whenever proteins not normally occurring in the circulation find their way into it, be this either the result of physiologic processes as in pregnancy, or due to the action of certain pathogenic organisms which by their presence bring about abnormal changes in the cell protoplasm. Within certain limits the organism will be stimulated by the presence of these complex proteins in the blood to the production of enzymes capable of splitting them into their simpler components, which are either assimilated or eliminated by the organism. The function of these enzymes in the blood is in this

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