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Article
March 28, 1914

THE ETIOLOGY OF HODGKIN'S DISEASE

JAMA. 1914;LXII(13):1019-1020. doi:10.1001/jama.1914.02560380043023
Abstract

In this brief account of some interesting recent work on the cause of a heretofore obscure disease, the name "Hodgkin's disease" is used as synonymous with lymphomatosis granulomatosa of certain European writers. Formerly included under pseudoleukemia and no doubt confused with different diseases, the common feature of which is enlargement of the lymphatic structures, Hodgkin's disease, in the sense in which the term is used here, is now recognized as a distinct disease characterized by peculiar changes in the lymph-glands and spleen of a chronic inflammatory nature, and consequently susceptible of definite diagnosis by means of microscopic examination of affected tissue. The microscopic picture shows a variety of cells with more or less fibrous tissue and also areas of necrosis. In addition to fibroblasts and lymphocytes there are large cells and giant-cells as well as plasma and eosinophil cells, the latter often in enormous numbers, and usually associated with polymorphonuclear

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