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November 25, 1905


JAMA. 1905;XLV(22):1658-1659. doi:10.1001/jama.1905.02510220044007

An interesting illustration of the application of clever surgical work to experimental physiology and pathology is the recent work of Carrel and Guthrie1 of the University of Chicago. They have successfully removed a kidney from a dog and transplanted it into the neck of the same animal, uniting the renal artery with the carotid artery, the renal vein with the jugular, and the ureter with the esophagus. The circulation was not impeded by the formation of thrombi, and was completely re-established in a short time. In this new location the transplanted kidney secreted urine about five times as fast as the normal one. The constituents of the urine were the same, but in composition the chlorids were increased, while the organic sulphates, pigments and urea of the normal kidney were greater. The transplanted kidney examined some days following the operation was larger and darker in color than normally and