While it is an undeniable fact that in syphilis of the nervous system the intravenous injection of neosalvarsan is capable of producing subjective improvement, nevertheless the peculiar isolation of the nervous system, and the relative impermeability of its membranes render treatment directed toward this system of little actual avail except subjectively. In tabes, it is true, the pains are frequently ameliorated, the gait is improved, and in rare instances optic atrophy is said to have been arrested by the intravenous injection of salvarsan. The proof, however, that these changes are not lasting, and that they really affect the progress of the disease but little, lies in the objective findings in the spinal fluid. These findings are little, if at all, changed by the treatment intravenously administered. Particularly is this true of the late manifestations of central nervous syphilis. It would seem, therefore, that the future treatment of syphilis in the
WILE UJ. THE TECHNIC OF THE INTRADURAL INJECTIONS OF NEOSALVARSAN IN SYPHILIS OF THE NERVOUS SYSTEMA PRELIMINARY REPORT. JAMA. 1914;LXII(15):1165–1166. doi:10.1001/jama.1914.02560400033012
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