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I have been incited to an investigation of this subject by the great frequency with which I have met with cases of various manifestations of uric acid in the Arkansas valley, where the drinking water is almost universally impregnated with alkali, and where the people partake largely of a meat diet.
Since reading Professor Haig's little book, "Uric Acid in the Causation of Disease," I have become extremely interested in the subject, and find in it a wide field for study and investigation.
That the alkali water is in some way accountable for so many cases, I am fully persuaded, but in so far as I have ransacked the authorities and the literature on the subject, I have failed to find any satisfactory explanation of the phenomenon. In this paper I do not presume to advance anything new, but only offer a few facts gleaned from a study of my
REED WW. A STUDY OF THE CAUSE AND EFFECT OF URIC ACID IN DISEASE, WITH SPECIAL REFERENCE TO ALKALINE DRINKING WATER. JAMA. 1897;XXIX(9):430–434. doi:10.1001/jama.1897.02440350028001g
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